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  • Bayesian Adaptive Design for Immunotherapy and Targeted Therapy

    Series series Mathematics and Statistics (R0)
    This book provides a comprehensive review of novel adaptive trial designs for targeted therapies and immunotherapies. This book covers a wide range of novel statistical designs for various clinical settings, including early phase dose-escalation study, proof-of-concept trials, and confirmatory studies with registrational. The book includes real-life examples and software to facilitate ... Leer más

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  • Model-Assisted Bayesian Designs for Dose Finding and Optimization

    Methods and Applications

    Series series Chapman & Hall/CRC Biostatistics Series
    Bayesian adaptive designs provide a critical approach to improve the efficiency and success of drug development that has been embraced by the US Food and Drug Administration (FDA). This is particularly important for early phase trials as they form the basis for the development and success of subsequent phase II and III trials.The objective of this book is to describe the state-of-the-art model ... Leer más

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  • Bayesian Designs for Phase I-II Clinical Trials

    Series series Chapman & Hall/CRC Biostatistics Series
    Reliably optimizing a new treatment in humans is a critical first step in clinical evaluation since choosing a suboptimal dose or schedule may lead to failure in later trials. At the same time, if promising preclinical results do not translate into a real treatment advance, it is important to determine this quickly and terminate the clinical evaluation process to avoid wasting resources.Bayesian ... Leer más

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  • 微生物學的世界

    Series series 科學文化
    911後聲名大噪的炭疽桿菌、令人聞之色變的SARS病毒、可以釀酒做麵包的酵母菌,都是我們熟悉的微生物。但是微生物到底有多小?包含了哪些種類?與日常生活又有何關係?在21世紀全球科技主流的生物科技中,微生物又扮演什麼角色?想知道答案嗎?請你翻開本書,與我們一同打開這扇進入微生物世界的大門吧!微生物包含了細菌、病毒、真菌、藻類、原生動物五大類,它們雖然體積小到連肉眼都看不見,卻跟人類的生活密不可分。本書以生動的筆法,勾勒出五大微生物的樣貌與特色,並針對相關的熱門生物科技與生活應用,深入淺出的加以介紹。作者簡介張碧芬台灣大學農業化學系畢業,台灣大學農業化學研究所博士。曾任台灣大學農業化學系技士,<... ... Leer más

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  • L’émergence des ONG en Chine

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    Depuis le début des réformes en 1978, l’Etat-Parti chinois a diminué son emprise sur la société et a accordé aux organisations non-gouvernementales (ONG) un nouvel espace de liberté. Mais, en même temps, il a limité leur marge de manœuvre de façon significative. Quelles sont les raisons qui expliquent cette stratégie apparemment contradictoire ? Pour répondre à cette question cette recherche a été ... Leer más

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