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  • Elispot for Rookies (and Experts Too)

    Series series Biomedical and Life Sciences (R0)
    This book provides basic, simple, and logical explanations for choices to be made to run the best Elispot possible. It allows the newcomer to truly understand the best options for specific protocol steps, reagents and materials, and provides even the experienced Elispot user with insight into best practices. The techniques presented here are supported by the author’s twenty-plus years of first ... Leer más

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  • Introduction to Molecular Medicine

    How will increased understanding of the human genome affect our ability to diagnose and treat disease? The subject of recombinant DNA technology is no longer limited to the research laboratory; it is being discussed in ever-widening medical circles. Introduction to Molecular Medicine is especially written for the physician who is not a genetics expert but wishes to understand this new science and ... Leer más

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  • Lentiviral Vectors and Gene Therapy

    Series series Biomedical and Life Sciences (R0)
    Gene therapy was conceived during the early and mid part of the 20th century. At first, it was considered a revolutionary biomedical procedure, which could potentially cure any disease for which the molecular bases were understood. Since then, gene therapy has gone through many stages and has evolved from a nearly unrealistic perspective to a real life application. Clinical efficacy in humans was ... Leer más

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  • Organelle Contact Sites

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    Edición de Thomas Simmen, Mitsuo Tagaya ...
    Series series Biomedical and Life Sciences (R0)
    This book provides the first comprehensive coverage of the quickly evolving research field of membrane contact sites (MCS). A total of 16 chapters explain their organization and role and unveil the significance of MCS for various diseases.MCS, the intracellular structures where organellar membranes come in close contact with one another, mediate the exchange of proteins, lipids, and ions. Via ... Leer más

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  • The Immunological Barriers to Regenerative Medicine

    Edición de Paul J. Fairchild ...
    Series series Biomedical and Life Sciences (R0)
    This volume offers an analysis of the scale and nature of the immunological issues facing regenerative medicine, drawing on the expertise of laboratories around the world who have taken up the challenge of applying their expertise in immunology to the vagaries of stem cell biology. In Part I, we explore the extent to which the principles of allograft rejection, learned over several decades from ... Leer más

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  • Hematopoietic Stem Cell Biology

    Edición de Motonari Kondo ...
    Series series Biomedical and Life Sciences (R0)
    In the summer of 1988, my developmental biology professor announced to the class that hematopoietic stem cells (HSCs) had finally been purified. Somehow, I never forgot the professor’s words. When I started working in Dr. Irv Weissman’s labo- tory at Stanford as a postdoctoral fellow, I realized that the findings mentioned by the professor were from Weissman’s laboratory and had been published in ... Leer más

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  • Perspectives in Translational Research in Life Sciences and Biomedicine

    Translational Outcomes Research in Life Sciences and Translational Medicine, Volume 1

    Series series Biomedical and Life Sciences (R0)
    The present book addresses the multi-disciplinary nature of Translational Outcomes Research, which is a watershed for nearly all the disciplines of Life and Health Sciences, along with the Materials Sciences including but not limited to Zoology, Botany, Microbiology, Biochemistry, Physiology, Nanotechnology, the Medical Sciences, Bioengineering, Biophysics, Medicinal Chemistry, Structural Biology, ... Leer más

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  • Recent Advances in the Pathophysiology of COPD

    Series series Medicine (R0)
    Chronic obstructive pulmonary disease (COPD) ranges amongst the commonest diseases in the world. The relentless progression of the disease causes a pressing need for a better understanding of and therapies for COPD. This volume provides state-of-the-art information on the pathophysiology of COPD including an outlook on new therapies. It is of interest to researchers and clinicians in academia as ... Leer más

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  • Decoding the Antibody Repertoire

    High Throughput Sequencing of Multiple Transcripts from Single B Cells

    Series series Biomedical and Life Sciences (R0)
    This thesis outlines the development of the very first technology for high-throughput analysis of paired heavy and light-chain antibody sequences, opening an entirely new window for antibody discovery and the investigation of adaptive immune responses to vaccines and diseases.Previous methods for high-throughput immune repertoire sequencing have been unable to provide information on the identity ... Leer más

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  • Cytokine Effector Functions in Tissues

    Edición de Maria Foti, Massimo Locati ...
    Cytokine Effector Functions in Tissues discusses the cytokines networks in the context of the specific-tissue environment. It is an up-to-date collection of articles that addresses the specific issue of how the cytokines are able to condition tissue specific homeostasis. The book helps the reader understand how cytokines network inside the tissues and highlights whether tissue-protection or ... Leer más

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  • Defense of Mucosal Surfaces: Pathogenesis, Immunity and Vaccines

    Series series Biomedical and Life Sciences (R0)
    Mucosal immunity encompasses a broad field of research that includes areas of epithelial cell and molecular biology, molecular and cellular immunology, microbiology, virology, and vaccinology. This volume presents up to date and concise discussions of concepts as well as recent advances. It provides an overview of the components of the mucosal immune system, and the basic science relevant to ... Leer más

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