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  • Rubidomycin

    A New Agent against Cancer

    Series series Medicine (R0)
    Trials in the treatment of the leukemias are sometimes based on a hypothesis, as in the case of exchange transfusion [33] or the use of antimetabolites [86]. Or they are conducted empirically as the results of chance observations, as in the case of the use of the nitrogen mustards, urethane, and the Vinca alkaloids. Or they lie between the two, aiming at making use of well established biological ... Leer más

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  • Pharmaceutical Competitive Intelligence for the Regulatory Affairs Professional

    Series series Medicine (R0)
    This Brief defines competitive intelligence (CI) as a tool for making investment decisions within the pharmaceutical industry. It provides an overview of processes that the regulatory affairs professional must take into account when evaluating data impacting product-based risk evaluations. These apply particularly to evaluations that focus on outputs such as regulatory approval, or the commercial ... Leer más

    $71.99 USD

  • Pharmaco-Imaging in Drug and Biologics Development

    Fundamentals and Applications

    Series series Biomedical and Life Sciences (R0)
    The volume aim to be a comprehensive overview of the drug and biologic development process that is often called “the valley of death” (pre-IND through approval) where high costs of studies and high rates of product failure are part of the drug development landscape. Imaging tools can serve in this period by adding high value data, the images and the kinetic information they can provide, and cost ... Leer más

    $152.99 USD

  • Validation of Alternative Methods for Toxicity Testing

    Edición de Chantra Eskes, Maurice Whelan ...
    Series series Biomedical and Life Sciences (R0)
    This book provides information on best practices and new thinking regarding the validation of alternative methods for toxicity testing. It covers the validation of experimental and computational methods and integrated approaches to testing and assessment. Validation strategies are discussed for methods employing the latest technologies such as tissue-on-a-chip systems, stem cells and ... Leer más

    $170.99 USD

  • A Picture is Worth a Thousand Tables

    Graphics in Life Sciences

    Edición de Andreas Krause, Michael OConnell ...
    This book is devoted to the graphics of patient data: good graphs enabling straight¬forward and intuitive interpretation, efficient creation, and straightforward interpretation. We focus on easy access to graphics of patient data: the intention is to show a large variety of graphs for different phases of drug development, together with a description of what the graph shows, what type of data it ... Leer más

    $170.99 USD

  • Antibiotic Pharmacokinetic/Pharmacodynamic Considerations in the Critically Ill

    Series series Medicine (R0)
    This book provides unique insights into the issues that drive modified dosing regimens for antibiotics in the critically ill. Leading international authors provide their commentary alongside a summary of existing evidence on how to effectively dose antibiotics.Severe infection frequently necessitates admission to the intensive care unit (ICU). Equally, nosocomial sepsis often complicates the ... Leer más

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  • Drug Interactions in Infectious Diseases: Mechanisms and Models of Drug Interactions

    Series series Medicine (R0)
    The 4th edition of Drug Interactions in Infectious Diseases is being split into two separate volumes – “Mechanisms and Models of Drug Interactions” and “Antimicrobial Drug Interactions”.This volume, “Mechanisms and Models of Drug Interactions,” delivers a text that enhances clinical knowledge of the complex mechanisms, risks, and consequences of drug interactions associated with antimicrobials, ... Leer más

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  • Recent Advances in Redox Active Plant and Microbial Products

    From Basic Chemistry to Widespread Applications in Medicine and Agriculture

    Series series Biomedical and Life Sciences (R0)
    Nature endows us with a treasure chest of Green Gold full of amazing ‘redox-active’ substances which interfere with numerous biological processes in our own body, in animals, bacteria, fungi and plants. Whilst such natural products are all around and also in us, we still do not fully understand how these compounds actually work. This book attempts to resolve some of the mysteries and riddles ... Leer más

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  • FDA Bioequivalence Standards

    Edición de Lawrence X. Yu, Bing V. Li ...
    Series series Biomedical and Life Sciences (R0)
    This comprehensive reference provides an in-depth discussion on state-of-the-art regulatory science in bioequivalence. In sixteen chapters, the volume explores a broad range of topics pertaining to bioequivalence, including its origin and principles, statistical considerations, food effect studies, conditions for waivers of bioequivalence studies, Biopharmaceutics Classification Systems, ... Leer más

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  • Pharmacokinetics in Drug Development

    Advances and Applications, Volume 3

    Edición de Peter L. Bonate, Danny R. Howard ...
    Series series Biomedical and Life Sciences (R0)
    The topics chosen for this volume were selected because they are some of the current development or technological issues facing drug development project teams. They regard the practical considerations for assessment of selected special development populations. For example, they include characterization of drug disposition in pregnant subjects, for measuring arrhythmic potential, for analysis tumor ... Leer más

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  • Citric Acid

    Series series Chemistry and Material Science (R0)
    This monograph is devoted to different aspects associated with citric acid, inorganic citrates and their aqueous and organic solutions. It includes information about properties, occurrence and technological applications of citric acid and inorganic citrates. Phase equilibria - melting, freezing, boiling, vapour pressures, solubilities of citric acid in water, organic solvents and ternary systems ... Leer más

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  • Sigma Proteins: Evolution of the Concept of Sigma Receptors

    Series Libro 244 - Handbook of Experimental Pharmacology
    Two sigma receptor subtypes have been proposed, sigma1 and 2. Much of our understanding of this system is based on biochemical and pharmacological characterization of the cloned sigma1 receptor subtype (Sigma1). It has become clear that sigma receptors are not canonical receptors. Sigma1 is highly conserved among mammalian species, however, it does not share significant homology with any other ... Leer más

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