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  • Fragment-based Drug Discovery

    Lessons and Outlook

    Series series Methods & Principles in Medicinal Chemistry
    From its origins as a niche technique more than 15 years ago, fragment-based approaches have become a major tool for drug and ligand discovery, often yielding results where other methods have failed. Written by the pioneers in the field, this book provides a comprehensive overview of current methods and applications of fragment-based discovery, as well as an outlook on where the field is headed ... Read more

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    Series series Mathematics and Statistics (R0)
    This book serves as a reference text for regulatory, industry and academic statisticians and also a handy manual for entry level Statisticians. Additionally it aims to stimulate academic interest in the field of Nonclinical Statistics and promote this as an important discipline in its own right. This text brings together for the first time in a single volume a comprehensive survey of methods ... Read more

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  • Case Studies in Medical Toxicology

    From the American College of Medical Toxicology

    Series series Biomedical and Life Sciences (R0)
    The ACMT National Case Conference (NCC) is a monthly discussion of novel or interesting cases in medical toxicology. Participation is through online webinar, and the conferences are recorded to allow for review at any time. The cases in this book are taken from recordings of NCC with edits and revisions by contributors and editors to demonstrate educational points. The majority of the case ... Read more

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  • Nanobiomaterials in Cancer Therapy

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    Edited by Alexandru Grumezescu ...
    Nanobiomaterials in Cancer Therapy presents the major applications of nanobiomaterials in oncology, offering an up-to-date overview of the latest research in this field. Utilizing nanobiomaterials, novel therapeutic approaches enable significant improvements in drug-loading capacity, formulation stability and drug efficiency. In this book, leading researchers from around the world share their ... Read more

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  • The New Drug Reimbursement Game

    A Regulator’s Guide to Playing and Winning

    Series series Medicine (R0)
    This comprehensive text presents a rigorous framework from within which regulators can respond strategically to the claim by the pharmaceutical industry that lower drug prices today lead to a loss for the population’s future health due to less innovation. It starts with a critical review of the empirical evidence of the return to consumers on their ongoing investment into high drug prices in order ... Read more

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  • Oral Delivery of Macromolecular Drugs

    Barriers, Strategies and Future Trends

    Recent and rapid progress in the field of biotechnology has resulted in an increasing number of novel macromolecular drugs with great promise for further advanced research and clinical application. However, the delivery of these macromolecular drugs by routes other than the parenteral route is difficult. The pipeline of macromolecular drugs derived from biotechnology presents a challenging ... Read more

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  • Protein-Protein Interactions in Drug Discovery

    Series Book 56 - Methods & Principles in Medicinal Chemistry
    Treating protein-protein interactions as a novel and highly promising class of drug targets, this volume introduces the underlying strategies step by step, from the biology of PPIs to biophysical and computational methods for their investigation.The main part of the book describes examples of protein targets for which small molecule modulators have been developed, covering such diverse fields as ... Read more

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    A comprehensive review on their mode of action, treatment of abuse and intoxication

    Series series Biomedical and Life Sciences (R0)
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    Edited by B. Saletu, P. Berner, L. Hollister ...
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    Neurodegeneration is one of the most important subjects of the investigation now and in the coming 21st century. Alzheimer's disease is the leading cause of dementia in the elderly people and Parkinson's disease is one of the major neurologic disorders with the prevalence between 1 and 2/1 000 population in advanced countries. Many others are suffering from intractable neurodegener ative disorders ... Read more

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