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  • Rethinking Cancer

    A New Paradigm for the Postgenomics Era

    Series series Vienna Series in Theoretical Biology
    Leading scientists argue for a new paradigm for cancer research, proposing a complex systems view of cancer supported by empirical evidence.Current consensus in cancer research explains cancer as a disease caused by specific mutations in certain genes. After dramatic advances in genome sequencing, never before have we known so much about the individual cancer cell--and yet never before has it been ... Read more

    $36.99 USD

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    The 2e of Molecular Diagnostics, the only book dealing with diagnosis on a molecular level, discusses current molecular biological techniques used to identify the underlying molecular defects in inherited disease. The book delves further into the principle and brief description of the technique, followed by examples from the authors' own expertise. Contributors to the 2e are well-known experts in ... Read more

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  • Drug-Acceptor Interactions

    Modeling Theoretical Tools to Test and Evaluate Experimental Equilibrium Effects

    Drug-Acceptor Interactions: Modeling theoretical tools to test and evaluate experimental equilibrium effects suggests novel theoretical tools to test and evaluate drug interactions seen with combinatorial drug therapy. The book provides an in-depth, yet controversial, exploration of existing tools for analysis of dose-response studies at equilibrium or steady state. The book is recommended reading ... Read more

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  • Debating Cancer: The Paradox In Cancer Research

    Cancer research is at a crossroads. Traditionally, cancer has been thought of as a disease of gene mutation, where the stepwise accumulation of cancer gene mutations is the key, and the identification of common gene mutations has been considered to be essential for diagnosis and treatment. Despite extensive research efforts and accumulated knowledge on cancer genes and pathways, the clinical ... Read more

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  • Aging and Health - A Systems Biology Perspective

    Aging is a major risk factor for chronic diseases, which in turn can provide information about the aging of a biological system. This publication serves as an introduction to systems biology and its application to biological aging. Key pathways and processes that impinge on aging are reviewed, and how they contribute to health and disease during aging is discussed. The evolution of this situation ... Read more

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  • Network Medicine

    Complex Systems in Human Disease and Therapeutics

    Big data, genomics, and quantitative approaches to network-based analysis are combining to advance the frontiers of medicine as never before. Network Medicine introduces this rapidly evolving field of medical research, which promises to revolutionize the diagnosis and treatment of human diseases. With contributions from leading experts that highlight the necessity of a team-based approach in ... Read more

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  • Basic Principles of Drug Discovery and Development

    Basic Principles of Drug Discovery and Development presents the multifaceted process of identifying a new drug in the modern era, providing comprehensive explanations of enabling technologies such as high throughput screening, structure based drug design, molecular modeling, pharmaceutical profiling, and translational medicine, all areas that have become critical steps in the successful ... Read more

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  • Systems Biology

    Functional Strategies of Living Organisms

    Series series Biomedical and Life Sciences (R0)
    This open-access textbook is an excellent introduction to systems biology, which has developed rapidly in recent years. It discusses the processes in living organisms in an integrated way, enabling the reader to understand the fundamental principles and cause-effect relationships in biology and biochemistry. The authors have chosen an original but at the same time clear way of presenting the ... Read more

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  • Cancer Stem Cells

    Philosophy and Therapies

    by Lucie Laplane ...
    An innovative theory proposes a new therapeutic strategy to break the stalemate in the war on cancer. It is called cancer stem cell (CSC) theory, and Lucie Laplane offers a comprehensive analysis, based on an original interdisciplinary approach that combines biology, biomedical history, and philosophy.Rather than treat cancer by aggressively trying to eliminate all cancerous cells—with harmful ... Read more

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  • Dynamics Of Cancer: Mathematical Foundations Of Oncology

    The book aims to provide an introduction to mathematical models that describe the dynamics of tumor growth and the evolution of tumor cells. It can be used as a textbook for advanced undergraduate or graduate courses, and also serves as a reference book for researchers. The book has a strong evolutionary component and reflects the viewpoint that cancer can be understood rationally through a ... Read more

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  • Systems Biology in Drug Discovery and Development

    Series Book 9 - Wiley Series on Technologies for the Pharmaceutical Industry
    The first book to focus on comprehensive systems biology as applied to drug discovery and developmentDrawing on real-life examples, Systems Biology in Drug Discovery and Development presents practical applications of systems biology to the multiple phases of drug discovery and development. This book explains how the integration of knowledge from multiple sources, and the models that best represent ... Read more

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  • Cancer Risk Evaluation

    Methods and Trends

    An overview of the different approaches to cancer risk assessment of environmental factors - including "-omics" technologies, discussing the strengths and weaknesses of the methods in different fields. The main focus is on the carcinogenic effects of ionizing and non-ionizing radiation, demonstrating the difficulties in accurately assessing those factors that may or may not pose a significant ... Read more

    $90.00 USD