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  • Dental Stem Cells

    Collections series Biomedical and Life Sciences (R0)
    This book explores Dental Stem Cell (DSC) biology, from a review of basic concepts for cell culture, to isolation, self-renewal, multipotency and differentiation, regulation by molecular medicine, and prospective research areas for regenerative medicine. The first seven chapters delve into basic DSC properties, vital signaling pathways involved in differentiation, pluripotency, iPS cell ... En savoir plus

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    Collections series Biomedical and Life Sciences (R0)
    The existence of ‘cancer stem cells’ (CSCs) has been a topic of heated debate for the last few years within the field of cancer biology. Their continuous characterization in a variety of solid tumors has lead to an abundance of evidence supporting their existence. CSCs are believed to be responsible for resistance against conventional treatment regimes of chemotherapy and radiation, ultimately, ... En savoir plus

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  • Computational Modeling Of Gene Regulatory Networks - A Primer

    par Hamid Bolouri ...
    This book serves as an introduction to the myriad computational approaches to gene regulatory modeling and analysis, and is written specifically with experimental biologists in mind. Mathematical jargon is avoided and explanations are given in intuitive terms. In cases where equations are unavoidable, they are derived from first principles or, at the very least, an intuitive description is ... En savoir plus

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  • Big Mechanisms in Systems Biology

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    Big Mechanisms in Systems Biology: Big Data Mining, Network Modeling, and Genome-Wide Data Identification explains big mechanisms of systems biology by system identification and big data mining methods using models of biological systems. Systems biology is currently undergoing revolutionary changes in response to the integration of powerful technologies. Faced with a large volume of available ... En savoir plus

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  • Stem Cell Biology and Regenerative Medicine in Ophthalmology

    Modifié par Stephen Tsang ...
    Collections series Biomedical and Life Sciences (R0)
    Patient specific and disease specific stem cell lines have already introduced groundbreaking advances into the research and practice of ophthalmology. This volume provides a comprehensive and engaging overview of the latest innovations in the field. Twelve chapters discuss the fastest growing areas in ophthalmological stem cell research, from disease modelling, drug screening and gene targeting to ... En savoir plus

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  • Hypoxia and Cancer

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    Modifié par Giovanni Melillo ...
    Collections series Biomedical and Life Sciences (R0)
    The imbalance between rapidly proliferating tumor cells and inadequate and inefficient tumor vasculature leads to a decrease in oxygen levels (hypoxia and/or anoxia) in tumor tissues. Intra-tumor hypoxia profoundly affects the biological behavior of cancer cells, which become resistant to conventional therapies and acquire a more invasive and metastatic phenotype. Hypoxia is a hallmark of the ... En savoir plus

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  • Regenerative Medicine: Laboratory to Clinic

    Modifié par Asok Mukhopadhyay ...
    This book discusses the two different cellular approaches that are pursued in regenerative medicine: cell therapy and tissue engineering. It examines in detail the therapeutic application of hematopoietic stem cells in marrow regeneration, multi-potent mesenchymal stem cells (MSCs), also referred to as mesenchymal stromal cells. The interest in MSCs can be seen in more than 150 clinical trials, ... En savoir plus

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  • Neurological Regeneration

    Modifié par Phuc Van Pham ...
    Collections series Biomedical and Life Sciences (R0)
    This invaluable resource explores the regenerative potential of stem cells in the nervous system, with a focus on clinical applications. The expertly authored chapters discuss cell-based therapies for spinal cord injury and regeneration, traumatic brain injury, glioblastoma, Parkinson's Disease, ischemic stroke, cell banking, human embryonic stem cells and related concerns, harvesting of adipose ... En savoir plus

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  • Decoding the Antibody Repertoire

    High Throughput Sequencing of Multiple Transcripts from Single B Cells

    par Brandon DeKosky ...
    Collections series Biomedical and Life Sciences (R0)
    This thesis outlines the development of the very first technology for high-throughput analysis of paired heavy and light-chain antibody sequences, opening an entirely new window for antibody discovery and the investigation of adaptive immune responses to vaccines and diseases.Previous methods for high-throughput immune repertoire sequencing have been unable to provide information on the identity ... En savoir plus

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  • Innovations in Molecular Mechanisms and Tissue Engineering

    Modifié par Jeanne Wilson-Rawls, Kenro Kusumi ...
    Collections series Biomedical and Life Sciences (R0)
    This book marries stem cell biology, tissue engineering, and regenerative biology into a single, interdisciplinary volume. The chapters also explore embryonic stem cells, induced pluripotent stem cells, cardiovascular regeneration, skeletal development, inflammation, polymeric biomaterials, neural injury, cartilage regeneration, regeneration in ambystoma, models for regeneration using salamander ... En savoir plus

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  • Cancer Stem Cells in Solid Tumors

    Modifié par Alison L. Allan ...
    Collections series Biomedical and Life Sciences (R0)
    The “cancer stem cell” hypothesis postulates that cancer arises from a subpopulation of tumor-initiating cells or cancer stem cells (CSCs). While the idea of cancer stem cells has been around for more than a hundred years, evidence from the fields of hematology and cancer biology has now demonstrated the critical role of stem cells in hematological malignancies and suggested that these same ... En savoir plus

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  • Stem Cells in Modeling Human Genetic Diseases

    Collections series Biomedical and Life Sciences (R0)
    While most stem cell books focus on basic aspects and/or cell therapy, this book emphasizes the relevance of stem cells obtained from patients, the so-called “patients in a petri dish” as tools to investigate human genetic diseases for which there are no available effective treatment. Chapters embrace several examples of the use of iPS cell technology, a recent Nobel Prize-winning scientific ... En savoir plus

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