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  • Gene Transfer and Expression in Mammalian Cells

    Edited by S.C. Makrides ...
    Series Book 38 - New Comprehensive Biochemistry
    The production of proteins in mammalian cells is an important tool in numerous scientific and commercial areas. For example, proteins for human therapy, vaccination or diagnostic applications are typically produced in mammalian cells. Gene cloning, protein engineering, biochemical and biophysical characterization of proteins also require the use of gene expression in mammalian cells. Other ... Read more

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    With over two hundred types of cancer diagnosed to date, researchers the world over have been forced to rapidly update their understanding of the biology of cancer. In fact, only the study of the basic cellular processes, and how these are altered in cancer cells, can ultimately provide a background for rational therapies. Bringing together the state-of-the-art contributions of international ... Read more

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  • Computer-Aided Drug Design and Delivery Systems

    THE LATEST BREAKTHROUGHS IN COMPUTER-AIDED DRUG DESIGN AND DELIVERYThis definitive text provides in-depth information on computer-assisted techniques for discovering, designing, and optimizing new, effective, and safe drugs. Computer-Aided Drug Design and Delivery Systems offers objective and quantitative data on the use and delivery of drugs in humans. Enabling technologies such as bioinformatics ... Read more

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  • Regenerative Medicine Ethics

    Governing Research and Knowledge Practices

    Edited by Linda F. Hogle ...
    Series series Biomedical and Life Sciences (R0)
    This book puts the ethics, policy and politics of stem cells into context in a way that helps readers understand why past and current issues have developed the way they have and what the implications are for their work going forward. It also addresses emerging issues as the field progresses towards clinical and industrial uses.While there is a superabundance of material on the ethics of embryo use ... Read more

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  • Adult Stem Cells

    Biology and Methods of Analysis

    Edited by Donald G. Phinney ...
    Series series Biomedical and Life Sciences (R0)
    This is comprehensive overview of a vital area of scientific enquiry, which covers a broad spectrum of issues. With contributions from some of the key researchers in the field, Adult Stem Cells: Biology and Methods of Analysis offers readers a historical perspective as well as unique insights into cutting-edge thoughts. The volume contextualizes the recent discovery of stem/progenitor cell ... Read more

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  • Decoding the Antibody Repertoire

    High Throughput Sequencing of Multiple Transcripts from Single B Cells

    Series series Biomedical and Life Sciences (R0)
    This thesis outlines the development of the very first technology for high-throughput analysis of paired heavy and light-chain antibody sequences, opening an entirely new window for antibody discovery and the investigation of adaptive immune responses to vaccines and diseases.Previous methods for high-throughput immune repertoire sequencing have been unable to provide information on the identity ... Read more

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  • Perspectives of Stem Cells

    From tools for studying mechanisms of neuronal differentiation towards therapy

    Edited by Henning Ulrich ...
    Series series Biomedical and Life Sciences (R0)
    Stem cells are fascinating cell types. They can replicate themselves forever while retaining the potential to generate progeny with speci?c functions. Because of these special properties, stem cells have been subjects of intensive investigation, from understanding basic mechanisms underlying tissue generation, to modeling human diseases, to application for cell replacement therapy. Stem cells come ... Read more

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  • Endogenous Stem Cell-Based Brain Remodeling in Mammals

    Series series Biomedical and Life Sciences (R0)
    This text highlights the endogenous regenerative potential of the central nervous system in neonates and juveniles and discusses possible ways it might be manipulated for medical purposes. The first section provides a descriptive summary of the salient steps of human brain development with a discussion of comparisons with other mammalian brains. It also provides a historical perspective on our ... Read more

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  • Mesenchymal Stem Cells and Immunomodulation

    Series series Biomedical and Life Sciences (R0)
    This essential volume explores mesenchymal stem cells (MSCs) and their potential to suppress immune-mediated inflammation. The chapters examine applications in autoimmune diseases such as lupus, rheumatoid arthritis and multiple sclerosis; blood cancers such as leukemia and lymphoma; and reproductive complications, specifically pre-term labor and use of MSCs in vitro and in animal models to ... Read more

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  • Essentials of Mesenchymal Stem Cell Biology and Its Clinical Translation

    Edited by Robert Chunhua Zhao ...
    Mesenchymal stem cells (MSCs), a type of adult stem cells, have attracted the attention of scientists and physicians alike due to their unique biological properties and potential for disease treatment. As stem cell research is complex and progressing rapidly, it is important that the experts in this field share their views and perspectives. This book, co-edited by leading global researchers, is ... Read more

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  • Calcium Handling in hiPSC-Derived Cardiomyocytes

    Series series Biomedical and Life Sciences (R0)
    Calcium is crucial in governing contractile activities of myofilaments in cardiomyocytes, any defeats in calcium homeostasis of the cells would adversely affect heart pumping action. The characterization of calcium handling properties in human induced pluripotent stem cell-derived cardiomyocytes (iPS-CMCs) is of significant interest and pertinent to the stem cell and cardiac regenerative field ... Read more

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