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Showing 1 - 12 of 12 results for “r scott obach”
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  • Drug Metabolizing Enzymes

    Cytochrome P450 and Other Enzymes in Drug Discovery and Development

    Edited by Jae Lee, R. Scott Obach, Michael B. Fisher ...
    Critical in the elimination of drugs and other xenobiotics from the body, cytochrome P450 has strong bearing on scientific assessments of genetic polymorphism in metabolism, possible drug-drug interactions, and bioavailability of candidate drugs. This text systematizes findings on P450 and similar enzymes--as well as parallel issues shaping the pharmaceutical industry--to promote the next ... Read more

    $394.99 CAD

  • Reactive Drug Metabolites

    by Deepak Dalvie, R. Scott Obach, Raimund Mannhold, Hugo Kubinyi, Gerd Folkers, Dennis A. Smith, Amit S. Kalgutkar ...
    Series Book 55 - Methods & Principles in Medicinal Chemistry
    Closing a gap in the scientifi c literature, this first comprehensive introduction to the topic is based on current best practice in one of the largestpharmaceutical companies worldwide. The first chapters trace the development of our understanding of drug metabolite toxicity, covering basic concepts and techniques in the process, while the second part details chemical toxicophores that are prone ... Read more

    $188.99 CAD

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  • Textbook of Drug Design and Discovery

    Edited by Kristian Stromgaard, Povl Krogsgaard-Larsen, Ulf Madsen ...
    Building on the success of the previous editions, the Textbook of Drug Design and Discovery, Fifth Edition, has been thoroughly revised and updated to provide a complete source of information on all facets of drug design and discovery for students of chemistry, pharmacy, pharmacology, biochemistry, and medicine. The information is presented in an up-to-date review form with an underlying and ... Read more

    $108.99 CAD

  • Medicinal Chemistry of Anticancer Drugs

    by Carmen Avendaño, J. Carlos Menéndez ...
    Antitumor chemotherapy is nowadays a very active field of research, and a huge amount of information on the topic is generated every year. Although many books are available that deal with clinical aspects of cancer chemotherapy, this book addresses the need for an updated treatment from the point of view of medicinal chemistry and drug design. The focus of Medicinal Chemistry of Anticancer Drugs ... Read more

    $181.59 CAD

  • The Organic Chemistry of Drug Design and Drug Action

    by Richard B. Silverman ...
    Standard medicinal chemistry courses and texts are organized by classes of drugs with an emphasis on descriptions of their biological and pharmacological effects. This book represents a new approach based on physical organic chemical principles and reaction mechanisms that allow the reader to extrapolate to many related classes of drug molecules. The Second Edition reflects the significant changes ... Read more

    $93.59 CAD

  • Protein Misfolding Diseases

    Current and Emerging Principles and Therapies

    Edited by Marina Ramirez-Alvarado, Jeffery W. Kelly, Christopher M. Dobson ...
    Series Book 14 - Wiley Series in Protein and Peptide Science
    An increasingly aging population will add to the number of individuals suffering from amyloid. Protein Misfolding Diseases provides a systematic overview of the current and emerging therapies for these types of protein misfolding diseases, including Alzheimer's, Parkinson's, and Mad Cow. The book emphasizes therapeutics in an amyloid disease context to help students, faculty, scientific ... Read more

    $282.99 CAD

  • Natural Products in Medicinal Chemistry

    by Hugo Kubinyi, Gerd Folkers, Raimund Mannhold ...
    Series Book 60 - Methods & Principles in Medicinal Chemistry
    The inspiration provided by biologically active natural products to conceive of hybrids, congeners, analogs and unnatural variants is discussed by experts in the field in 16 highly informative chapters.Using well-documented studies over the past decade, this timely monograph demonstrates the current importance and future potential of natural products as starting points for the development of new ... Read more

    $197.99 CAD

  • Medicinal Chemistry of Anticancer Drugs

    by Carmen Avendaño, J. Carlos Menéndez ...
    Medicinal Chemistry of Anticancer Drugs, Second Edition, provides an updated treatment from the point of view of medicinal chemistry and drug design, focusing on the mechanism of action of antitumor drugs from the molecular level, and on the relationship between chemical structure and chemical and biochemical reactivity of antitumor agents. Antitumor chemotherapy is a very active field of research ... Read more

    $176.79 CAD

  • Therapeutic Monoclonal Antibodies

    From Bench to Clinic

    Edited by Zhiqiang An ...
    70-chapter authoritative reference that covers therapeutic monoclonal antibody discovery, development, and clinical applications while incorporating principles, experimental data, and methodologies.First book to address the discovery and development of antibody therapeutics in their entirety.Most chapters contain experimental data to illustrate the principles described in them.Authors provide ... Read more

    $265.99 CAD

  • Bioinorganic Medicinal Chemistry

    Edited by Enzo Alessio ...
    This book gives a comprehensive overview about medicinal inorganic chemistry. Topics like targeting strategies, mechanism of action, Pt-based antitumor drugs, radiopharmaceuticals are covered in detail and offer the reader an in-depth overview about this important topic. ... Read more

    $207.99 CAD

  • Cytochrome P450

    Structure, Mechanism, and Biochemistry

    Edited by Paul R. Ortiz de Montellano ...
    Series series Medicine (R0)
    This authoritative Fourth Edition summarizes the advances of the past decade concerning the structure, mechanism, and biochemistry of cytochrome P450 enzymes, with sufficient coverage of earlier work to make each chapter a comprehensive review of the field. Thirteen chapters are divided into two detailed volumes, the first covering the fundamentals of cytochrome P450 biochemistry, as well as the ... Read more

    $499.99 CAD

  • Transmembrane Dynamics of Lipids

    by Andreas Herrmann ...
    Series Book 9 - Wiley Series in Protein and Peptide Science
    The first and only book devoted entirely to MEMBRANE LIPID ASYMMETRY AND ITS BIOLOGICAL IMPLICATIONSTransmembrane Dynamics of Lipids is comprised of contributions from expert authors from leading research groups that present up-to-date quantitative data on the formation, stability, and biological consequences of the asymmetrical organization of lipids in cell membranes.Incorporating an impressive ... Read more

    $155.99 CAD