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Showing 1 - 12 of 12 results for “olavi pelkonen”
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  • Interindividual Variability in Human Drug Metabolism

    Edited by Gian Maria Pacifici, Olavi Pelkonen ...
    The book provides an exhaustive, authoritative and updated review on the interindividual variability in drug metabolism in humans. Four chapters address the general background: genetic factors causing variability, interethnic variability, environmental factors and developing and ageing as sources of variability. Six chapters address variability of ... Read more

    $563.99 CAD

  • Toxicology of Herbal Products

    Edited by Olavi Pelkonen, Pierre Duez, Pia Maarit Vuorela, Heikki Vuorela ...
    Series series Biomedical and Life Sciences (R0)
    This volume provides a comprehensive overview of the hazards inherent in herbal medicinal products, with systematic coverage of major toxicities. Topics include composition and quality control, toxicokinetics, interactions, safety pharmacology, approaches to studying complex mixtures including metabolomics and systems network pharmacology, and long-term toxicity. The volume also discusses various ... Read more

    $218.99 CAD

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  • Handbook of Cell Signaling

    Edited by Ralph A. Bradshaw, Edward A. Dennis ...
    Series series Cell Biology
    Handbook of Cell Signaling, Three-Volume Set, 2e, is a comprehensive work covering all aspects of intracellular signal processing, including extra/intracellular membrane receptors, signal transduction, gene expression/translation, and cellular/organotypic signal responses. The second edition is an up-to-date, expanded reference with each section edited by a recognized expert in the field. Tabular ... Read more

    $472.79 CAD

  • Cancer Stem Cells

    Edited by William L. Farrar, PhD ...
    A remarkable paradigm shift has occurred in recent years regarding the biological origins of cancer. The cancer stem cell hypothesis challenged the foundational notions of cancer, and the therapeutic implications have been profound. Compelling evidence indicates that errors in the development of a small subset of adult stem cells can lead to cancer. Only this small sub-population of cells has the ... Read more

    $122.99 CAD

  • Cytochrome P450 2D6

    Structure, Function, Regulation and Polymorphism

    by Shufeng Zhou ...
    Cytochromes are proteinsthat catalyze electron transfer reactions of well-known metabolic pathways and are classified in various superfamilies. The CYP, or P450, superfamily accounts for 90% of the oxidative metabolism of clinical drugs. One member of this superfamily, P450 2D6 (or CYP2D6), singlehandedly metabolizes about 25% of all medications in the human liver. Cytochrome P450 2D6: Structure, ... Read more

    $100.99 CAD

  • The DNA Damage Response: Implications on Cancer Formation and Treatment

    Edited by Yosef Shiloh, Kum Kum Khanna ...
    Series series Biomedical and Life Sciences (R0)
    The ?eld of cellular responses to DNA damage has attained widespread recognition and interest in recent years commensurate with its fundamental role in the ma- tenance of genomic stability. These responses, which are essential to preventing cellular death or malignant transformation, are organized into a sophisticated s- tem designated the “DNA damage response”. This system operates in all living ... Read more

    $179.99 CAD

  • DNA Repair of Cancer Stem Cells

    Edited by Elain Hurt, Stephanie M Cabarcas, Lesley A Mathews ...
    Series series Biomedical and Life Sciences (R0)
    The existence of ‘cancer stem cells’ (CSCs) has been a topic of heated debate for the last few years within the field of cancer biology. Their continuous characterization in a variety of solid tumors has lead to an abundance of evidence supporting their existence. CSCs are believed to be responsible for resistance against conventional treatment regimes of chemotherapy and radiation, ultimately, ... Read more

    $179.99 CAD

  • Anticancer Drug Development

    Edited by Bruce C. Baguley, David J. Kerr ...
    Here in a single source is a complete spectrum of ideas on the development of new anticancer drugs. Containing concise reviews of multidisciplinary fields of research, this book offers a wealth of ideas on current and future molecular targets for drug design, including signal transduction, the cell division cycle, and programmed cell death. Detailed descriptions of sources for new drugs and ... Read more

    $159.99 CAD

  • Cancer Drug Design and Discovery

    Edited by Stephen Neidle ...
    Cancer Drug Design and Discovery, Second Edition is an important reference on the underlying principles for the design and subsequent development of new anticancer small molecule agents. New chapters have been added to this edition on areas of particular interest and therapeutic promise, including cancer genomics and personalized medicine, DNA-targeted agents and more. This book includes several ... Read more

    $115.19 CAD

  • Pharmacogenomics of Human Drug Transporters

    Clinical Impacts

    by Toshihisa Ishikawa, Richard B. Kim, Jörg König ...
    Sets the foundation for safer, more effective drug therapiesWith this book as their guide, readers will discover how to apply our current understanding of the pharmacogenomics of drug transporters to advance their own drug discovery and development efforts. In particular, the book explains how new findings in the field now enable researchers to more accurately predict drug interactions and adverse ... Read more

    $191.99 CAD

  • Post-transcriptional Mechanisms in Endocrine Regulation

    Edited by K.M.J. Menon, PhD, Aaron Goldstrohm, PhD ...
    This book examines how post-transcriptional mechanisms control endocrine function. This includes newly identified regulatory mechanisms involved in hormone biosynthesis, control of hormone receptors and the outputs of hormone mediated signal transduction. Chapters address endocrine hormones including protein peptide/peptide, steroid, and non-steroidal hormones. The impacts of these mechanisms on ... Read more

    $218.99 CAD

  • Signal Transduction in Cancer

    Edited by David A. Frank ...
    Series Book 115 - Cancer Treatment and Research
    One of the most exciting areas of cancer research now is the development of agents which can target signal transduction pathways that are activated inappropriately in malignant cells. The understanding of the molecular abnormalities which distinguish malignant cells from their normal counterparts has grown tremendously.This volume summarizes the current research on the role that signal ... Read more

    $179.99 CAD