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Showing 1 - 12 of 12 results for “ingo k mellinghoff”
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  • Therapeutic Kinase Inhibitors

    Edited by Ingo K. Mellinghoff, Charles L. Sawyers ...
    Series series Biomedical and Life Sciences (R0)
    Cancer drug development is currently undergoing a profound shift. Drugs targeting fundamental cellular processes such DNA-replication and microtubule function, often referred to as “chemotherapy” and still the backbone of most cancer treatment regimens, are increasingly being complemented by or replaced with kinase inhibitors. This new class of drugs targets enzymes which provide growth and ... Read more

    $179.99 CAD

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  • Targeting Protein Kinases for Cancer Therapy

    by David J. Matthews, Mary E. Gerritsen ...
    An expert guide to targeting protein kinases in cancer therapyResearch has shown that protein kinases can instigate the formation and spread of cancer when they transmit faulty signals inside cells. Because of this fact, pharmaceutical scientists have targeted kinases for intensive study, and have been working to develop medicinal roadblocks to sever their malignant means of communication.Complete ... Read more

    $191.99 CAD

  • Lymphomas

    by John W. Sweetenham, MD, Jame Abraham, MD, FACP ...
    Series series Emerging Cancer Therapeutics
    Emerging Cancer Therapeutics is a trinary hard cover periodical that is designed to provide an up-to-date evidence-based review of a dedicated emerging cancer therapy topic of interest to clinicians and scientists involved in the care of patients receiving cancer treatment. It will serve as both a reference and instructional tool for students, housestaff, fellows, practicing clinical oncologists, ... Read more

    $132.99 CAD

  • The Treatment of Myeloid Malignancies with Kinase Inhibitors, An Issue of Hematology/Oncology Clinics of North America

    by Ann Mullally ...
    Series Book Volume 31-4 - The Clinics: Internal Medicine
    This issue of Hematology/Oncology Clinics will focus on The Treatment of Myeloid Malignancies with Kinase Inhibitors. Articles will focus on: Targeting aberrant signaling in myeloid malignancies: promise versus reality; The development and use of imatinib for the treatment of chronic myelogenous leukemia; Mechanisms of resistance to ABL kinase inhibition in CML and the development of next ... Read more

    $106.99 CAD

  • Resistance of Cancer Cells to CTL-Mediated Immunotherapy

    Edited by Benjamin Bonavida, Salem Chouaib ...
    Series series Biomedical and Life Sciences (R0)
    This comprehensive volume explores the latest research on the mechanisms of resistance in cancer cells to CTL-mediated immunotherapy. Chapter topics discuss cell-mediated immunity as the result of cytotoxic T-lymphocytes (CTL) directed specifically against cancer cells. In addition, the volume reviews how CTL mediate the cytotoxic activity, in large part, by the indication of apoptosis; hence, ... Read more

    $115.99 CAD

  • Novel Developments in Stem Cell Mobilization

    Focus on CXCR4

    Edited by Stefan Fruehauf, Gary Calandra, W. Jens Zeller ...
    Series series Biomedical and Life Sciences (R0)
    Recently the CXCR4/CXCL12-axis has been recognized as one of the pivotal adhesion pathways by which hematopoietic stem cells are retained in the bone marrow. CXCR4 antagonists with different chemical specification are being developed. Pharmacology research guides the way to the rational development effective antagonists. One antagonist, plerixafor, is clinically approved now for stem cell ... Read more

    $179.99 CAD

  • Molecular Aspects of Hematologic Malignancies

    Diagnostic Tools and Clinical Applications

    Edited by Michal Witt, Malgorzata Dawidowska, Tomasz Szczepanski ...
    Series series Biomedical and Life Sciences (R0)
    This book provides a state-of-the-art approach to the molecular basis of hematologic diseases and its translation into improved diagnostics and novel therapeutic strategies. Several representative hemato-oncologic malignancies are analyzed in detail: acute lymphoblastic leukemia, acute myeloid leukemia, B-cell Non-Hodgkin lymphomas, multiple myeloma, chronic lymphocytic leukemia, chronic myeloid ... Read more

    $179.99 CAD

  • Myelodysplastic Syndromes

    by H. Joachim Deeg, David T. Bowen, Steven D. Gore, Torsten Haferlach, Michelle M. Le Beau, Charlotte Niemeyer ...
    Series series Medicine (R0)
    The diagnosis of myelodysplastic syndromes (MDS), a heterogeneous group of clonal hematopoietic disorders, is being made with increasing frequency over the past decade owing to increased recognition, improved understanding, and an aging population. This book, completely updated since the first edition, summarizes in a concise and focused way the current knowledge of all aspects of MDS. Clinical ... Read more

    $128.99 CAD

  • Anticancer Drug Development

    Edited by Bruce C. Baguley, David J. Kerr ...
    Here in a single source is a complete spectrum of ideas on the development of new anticancer drugs. Containing concise reviews of multidisciplinary fields of research, this book offers a wealth of ideas on current and future molecular targets for drug design, including signal transduction, the cell division cycle, and programmed cell death. Detailed descriptions of sources for new drugs and ... Read more

    $159.99 CAD

  • Hematologic Cancers: From Molecular Pathobiology to Targeted Therapeutics

    Edited by Jianguo Tao, Eduardo Sotomayor ...
    Series series Medicine (R0)
    In the last decade, there has been a remarkable explosion of knowledge in hematologic cancer from basic molecular biology and pathology to clinical therapy. This has led to many new advance and insights in the understanding of pathobiology of malignant hematology. New knowledge of disease molecular pathology, cytogenetic, epigenetic and genomic alterations have provided new strategies to attack ... Read more

    $179.99 CAD

  • Targeted Therapy in Translational Cancer Research

    by Maurie Markman, Ernest Hawk, Robert C. Bast Jr. ...
    Series series Translational Oncology
    Targeted Therapy in Translational Cancer Research for the Translational Oncology series provides a comprehensive overview of recent developments in our understanding of tumor biology, elucidates the roles of targets and pathways involved in carcinogenesis, and describes current state-of-the-art anticancer therapy, as well as the most promising areas of translational research and targeted therapy ... Read more

    $179.99 CAD

  • Drug-Drug Interactions for Therapeutic Biologics

    by Honghui Zhou, Bernd Meibohm ...
    Strategize, plan, and execute comprehensive drug-drug interaction assessments for therapeutic biologicsOffering both theory and practical guidance, this book fully explores drug-drug interaction assessments for therapeutic biologics during the drug development process. It draws together and analyzes all the latest findings and practices in order to present our current understanding of the topic ... Read more

    $159.99 CAD